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Disease-Modifying Drugs Reduce Cortical Lesion Accumulation and Atrophy Progression in Relapsing-Remitting Multiple Sclerosis: Results from a 48-Month Extension Study
Joint Authors
Gallo, Paolo
Rinaldi, Francesca
Perini, Paola
Atzori, Matteo
Favaretto, Alice
Seppi, Dario
Source
Multiple Sclerosis International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Cortical lesions (CLs) and atrophy are pivotal in multiple sclerosis (MS) pathology.
This study determined the effect of disease modifying drugs (DMDs) on CL development and cortical atrophy progression in patients with relapsing-remitting MS (RRMS) over 48 months.
Patients (n=165) were randomized to sc IFN β-1a 44 μg, im IFN β-1a 30 μg, or glatiramer acetate 20 mg.
The reference population comprised 50 DMD-untreated patients with RRMS.
After 24 months, 43 of the untreated patients switched to DMDs.
The four groups of patients were followed up for an additional 24 months.
At 48 months the mean standard deviation number of new CLs was significantly lower in patients treated with sc IFN β-1a (1.4 ± 1.0, range 0–5) compared with im IFN β-1a (2.3 ± 1.3, range 0–6, P=0.004) and glatiramer acetate (2.2 ± 1.5, range 0–7, P=0.03).
Significant reductions in CL accumulation and new white matter and gadolinium-enhancing lesions were also observed in the 43 patients who switched to DMDs after 24 months, compared with the 24 months of no treatment.
Concluding, this study confirms that DMDs significantly reduce CL development and cortical atrophy progression compared with no treatment.
American Psychological Association (APA)
Rinaldi, Francesca& Perini, Paola& Atzori, Matteo& Favaretto, Alice& Seppi, Dario& Gallo, Paolo. 2015. Disease-Modifying Drugs Reduce Cortical Lesion Accumulation and Atrophy Progression in Relapsing-Remitting Multiple Sclerosis: Results from a 48-Month Extension Study. Multiple Sclerosis International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075277
Modern Language Association (MLA)
Rinaldi, Francesca…[et al.]. Disease-Modifying Drugs Reduce Cortical Lesion Accumulation and Atrophy Progression in Relapsing-Remitting Multiple Sclerosis: Results from a 48-Month Extension Study. Multiple Sclerosis International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1075277
American Medical Association (AMA)
Rinaldi, Francesca& Perini, Paola& Atzori, Matteo& Favaretto, Alice& Seppi, Dario& Gallo, Paolo. Disease-Modifying Drugs Reduce Cortical Lesion Accumulation and Atrophy Progression in Relapsing-Remitting Multiple Sclerosis: Results from a 48-Month Extension Study. Multiple Sclerosis International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075277