Neuroimaging of Natalizumab Complications in Multiple Sclerosis: PML and Other Associated Entities
Joint Authors
Nagae, Lidia
Nyberg, Eric
Honce, Justin Morris
Source
Multiple Sclerosis International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Natalizumab (Tysabri) is a monoclonal antibody (α4 integrin antagonist) approved for treatment of multiple sclerosis, both for patients who fail therapy with other disease modifying agents and for patients with aggressive disease.
Natalizumab is highly effective, resulting in significant decreases in rates of both relapse and disability accumulation, as well as marked decrease in MRI evidence of disease activity.
As such, utilization of natalizumab is increasing, and the presentation of its associated complications is increasing accordingly.
This review focuses on the clinical and neuroimaging features of the major complications associated with natalizumab therapy, focusing on the rare but devastating progressive multifocal leukoencephalopathy (PML).
Associated entities including PML associated immune reconstitution inflammatory syndrome (PML-IRIS) and the emerging phenomenon of rebound of MS disease activity after natalizumab discontinuation are also discussed.
Early recognition of neuroimaging features associated with these processes is critical in order to facilitate prompt diagnosis, treatment, and/or modification of therapies to improve patient outcomes.
American Psychological Association (APA)
Honce, Justin Morris& Nagae, Lidia& Nyberg, Eric. 2015. Neuroimaging of Natalizumab Complications in Multiple Sclerosis: PML and Other Associated Entities. Multiple Sclerosis International،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075286
Modern Language Association (MLA)
Honce, Justin Morris…[et al.]. Neuroimaging of Natalizumab Complications in Multiple Sclerosis: PML and Other Associated Entities. Multiple Sclerosis International No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075286
American Medical Association (AMA)
Honce, Justin Morris& Nagae, Lidia& Nyberg, Eric. Neuroimaging of Natalizumab Complications in Multiple Sclerosis: PML and Other Associated Entities. Multiple Sclerosis International. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075286