Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury
Joint Authors
Strazzer, Sandra
Rocca, Maria A.
Molteni, Erika
De Meo, Ermelinda
Recla, Monica
Valsasina, Paola
Arrigoni, Filippo
Galbiati, Susanna
Bardoni, Alessandra
Filippi, Massimo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We assessed abnormalities of brain functional magnetic resonance imaging (fMRI) activity during a sustained attention task (Conners’ Continuous Performance Test (CCPT)) in 20 right-handed pediatric acquired brain injury (ABI) patients versus 7 right-handed age-matched healthy controls, and we estimated the correlation of such abnormalities with clinical and cognitive deficits.
Patients underwent the Wechsler Intelligence Scale for Children (WISC), Wisconsin Card Sorting Test, and Functional Independence Measure (FIM) evaluations.
During fMRI, patients and controls activated regions of the attention network.
Compared to controls, ABI patients experienced a decreased average fMRI recruitment of the left cerebellum and a decreased deactivation of the left anterior cingulate cortex.
With increasing task demand, compared to controls, ABI patients had an impaired ability to increase the recruitment of several posterior regions of the attention network.
They also experienced a greater activation of frontal regions, which was correlated with worse performance on FIM, WISC, and fMRI CCPT.
Such abnormal brain recruitment was significantly influenced by the type of lesion (focal versus diffuse axonal injury) and time elapsed from the event.
Pediatric ABI patients experienced an inability to optimize attention network recruitment, especially when task difficulty was increased, which likely contributes to their clinical and cognitive deficits.
American Psychological Association (APA)
Strazzer, Sandra& Rocca, Maria A.& Molteni, Erika& De Meo, Ermelinda& Recla, Monica& Valsasina, Paola…[et al.]. 2015. Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury. Neural Plasticity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075289
Modern Language Association (MLA)
Strazzer, Sandra…[et al.]. Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury. Neural Plasticity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075289
American Medical Association (AMA)
Strazzer, Sandra& Rocca, Maria A.& Molteni, Erika& De Meo, Ermelinda& Recla, Monica& Valsasina, Paola…[et al.]. Altered Recruitment of the Attention Network Is Associated with Disability and Cognitive Impairment in Pediatric Patients with Acquired Brain Injury. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075289