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Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo
Joint Authors
Morara, Stefano
Colangelo, Anna Maria
Provini, Luciano
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Microglia-induced maladaptive plasticity is being recognized as a major cause of deleterious self-sustaining pathological processes that occur in neurodegenerative and neuroinflammatory diseases.
Microglia, the primary homeostatic guardian of the central nervous system, exert critical functions both during development, in neural circuit reshaping, and during adult life, in the brain physiological and pathological surveillance.
This delicate critical role can be disrupted by neural, but also peripheral, noxious stimuli that can prime microglia to become overreactive to a second noxious stimulus or worsen underlying pathological processes.
Among regulators of microglia, neuropeptides can play a major role.
Their receptors are widely expressed in microglial cells and neuropeptide challenge can potently influence microglial activity in vitro.
More relevantly, this regulator activity has been assessed also in vivo, in experimental models of brain diseases.
Neuropeptide action in the central nervous system has been associated with beneficial effects in neurodegenerative and neuroinflammatory pathological experimental models.
This review describes some of the mechanisms of the microglia maladaptive plasticity in vivo and how neuropeptide activity can represent a useful therapeutical target in a variety of human brain pathologies.
American Psychological Association (APA)
Morara, Stefano& Colangelo, Anna Maria& Provini, Luciano. 2015. Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo. Neural Plasticity،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075292
Modern Language Association (MLA)
Morara, Stefano…[et al.]. Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo. Neural Plasticity No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1075292
American Medical Association (AMA)
Morara, Stefano& Colangelo, Anna Maria& Provini, Luciano. Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075292