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Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1Kal-7Rac1 “Signalosome”
Joint Authors
Owczarek, Sylwia
Bang, Marie Louise
Berezin, Vladimir
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Neurexins (NXs) and neuroligins (NLs) are cell adhesion molecules that are localized at opposite sites of synaptic membranes.
They interact with each other to promote the assembly, maintenance, and function of synapses in the central nervous system.
Both NX and NL are cleaved from a membrane-attached intracellular domain in an activity-dependent manner, generating the soluble ectodomain of NX or NL.
Expression of the NX1 and NX3 genes in the brain appears to be regulated by a schizophrenia-related protein, DISC1.
Here, we show that soluble ecto-NX1β can regulate the expression of DISC1 and induce signaling downstream of DISC1.
We also show that NL1 binds to a well-characterized DISC1 interaction partner, Kal-7, and this interaction can be compromised by DISC1.
Our results indicate that the NX/NL synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia.
American Psychological Association (APA)
Owczarek, Sylwia& Bang, Marie Louise& Berezin, Vladimir. 2015. Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1Kal-7Rac1 “Signalosome”. Neural Plasticity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075297
Modern Language Association (MLA)
Owczarek, Sylwia…[et al.]. Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1Kal-7Rac1 “Signalosome”. Neural Plasticity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075297
American Medical Association (AMA)
Owczarek, Sylwia& Bang, Marie Louise& Berezin, Vladimir. Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1Kal-7Rac1 “Signalosome”. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075297