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Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function
Joint Authors
Licheri, Valentina
Talani, Giuseppe
Gorule, Ashish A.
Mostallino, Maria Cristina
Biggio, Giovanni
Sanna, Enrico
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Pregnancy needs complex pathways that together play a role in proper growth and protection of the fetus preventing its premature loss.
Changes during pregnancy and postpartum period include the manifold machinery of neuroactive steroids that plays a crucial role in neuronal excitability by local modulation of specific inhibitory receptors: the GABAA receptors.
Marked fluctuations in both blood and brain concentration of neuroactive steroids strongly contribute to GABAA receptor function and plasticity.
In this review, we listed several interesting results regarding the regulation and plasticity of GABAA receptor function during pregnancy and postpartum period in rats.
The increase in brain levels of neuroactive steroids during pregnancy and their sudden decrease immediately before delivery are causally related to changes in the expression/function of specific GABAA receptor subunits in the hippocampus.
These data suggest that alterations in GABAA receptor expression and function may be related to neurological and psychiatric disorders associated with crucial periods in women.
These findings could help to provide potential new treatments for these women’s disabling syndromes.
American Psychological Association (APA)
Licheri, Valentina& Talani, Giuseppe& Gorule, Ashish A.& Mostallino, Maria Cristina& Biggio, Giovanni& Sanna, Enrico. 2015. Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function. Neural Plasticity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075298
Modern Language Association (MLA)
Licheri, Valentina…[et al.]. Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function. Neural Plasticity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075298
American Medical Association (AMA)
Licheri, Valentina& Talani, Giuseppe& Gorule, Ashish A.& Mostallino, Maria Cristina& Biggio, Giovanni& Sanna, Enrico. Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075298