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New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc
Joint Authors
Morin, Jean-Pascal
Guzmán-Ramos, Kioko
Bermudez-Rattoni, Federico
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The mainstream view on the neurobiological mechanisms underlying memory formation states that memory traces reside on the network of cells activated during initial acquisition that becomes active again upon retrieval (reactivation).
These activation and reactivation processes have been called “conjunctive trace.” This process implies that singular molecular events must occur during acquisition, strengthening the connection between the implicated cells whose synchronous activity must underlie subsequent reactivations.
The strongest experimental support for the conjunctive trace model comes from the study of immediate early genes such as c-fos, zif268, and activity-regulated cytoskeletal-associated protein.
The expressions of these genes are reliably induced by behaviorally relevant neuronal activity and their products often play a central role in long-term memory formation.
In this review, we propose that the peculiar characteristics of Arc protein, such as its optimal expression after ongoing experience or familiar behavior, together with its versatile and central functions in synaptic plasticity could explain how familiarization and recognition memories are stored and preserved in the mammalian brain.
American Psychological Association (APA)
Morin, Jean-Pascal& Guzmán-Ramos, Kioko& Bermudez-Rattoni, Federico. 2015. New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc. Neural Plasticity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075301
Modern Language Association (MLA)
Morin, Jean-Pascal…[et al.]. New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc. Neural Plasticity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075301
American Medical Association (AMA)
Morin, Jean-Pascal& Guzmán-Ramos, Kioko& Bermudez-Rattoni, Federico. New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075301