In Vitro Studies of Neuronal Networks and Synaptic Plasticity in Invertebrates and in Mammals Using Multielectrode Arrays
Joint Authors
Ghirardi, Mirella
Massobrio, Paolo
Tessadori, Jacopo
Chiappalone, Michela
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-17
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Brain functions are strictly dependent on neural connections formed during development and modified during life.
The cellular and molecular mechanisms underlying synaptogenesis and plastic changes involved in learning and memory have been analyzed in detail in simple animals such as invertebrates and in circuits of mammalian brains mainly by intracellular recordings of neuronal activity.
In the last decades, the evolution of techniques such as microelectrode arrays (MEAs) that allow simultaneous, long-lasting, noninvasive, extracellular recordings from a large number of neurons has proven very useful to study long-term processes in neuronal networks in vivo and in vitro.
In this work, we start off by briefly reviewing the microelectrode array technology and the optimization of the coupling between neurons and microtransducers to detect subthreshold synaptic signals.
Then, we report MEA studies of circuit formation and activity in invertebrate models such as Lymnaea, Aplysia, and Helix.
In the following sections, we analyze plasticity and connectivity in cultures of mammalian dissociated neurons, focusing on spontaneous activity and electrical stimulation.
We conclude by discussing plasticity in closed-loop experiments.
American Psychological Association (APA)
Massobrio, Paolo& Tessadori, Jacopo& Chiappalone, Michela& Ghirardi, Mirella. 2015. In Vitro Studies of Neuronal Networks and Synaptic Plasticity in Invertebrates and in Mammals Using Multielectrode Arrays. Neural Plasticity،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1075305
Modern Language Association (MLA)
Massobrio, Paolo…[et al.]. In Vitro Studies of Neuronal Networks and Synaptic Plasticity in Invertebrates and in Mammals Using Multielectrode Arrays. Neural Plasticity No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1075305
American Medical Association (AMA)
Massobrio, Paolo& Tessadori, Jacopo& Chiappalone, Michela& Ghirardi, Mirella. In Vitro Studies of Neuronal Networks and Synaptic Plasticity in Invertebrates and in Mammals Using Multielectrode Arrays. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1075305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075305