Expression of p53 Target Genes in the Early Phase of Long-Term Potentiation in the Rat Hippocampal CA1 Area
Joint Authors
Lisachev, Pavel D.
Pustylnyak, Vladimir O.
Shtark, Mark B.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Gene expression plays an important role in the mechanisms of long-term potentiation (LTP), which is a widely accepted experimental model of synaptic plasticity.
We have studied the expression of at least 50 genes that are transcriptionally regulated by p53, as well as other genes that are related to p53-dependent processes, in the early phase of LTP.
Within 30 min after Schaffer collaterals (SC) tetanization, increases in the mRNA and protein levels of Bax, which are upregulated by p53, and a decrease in the mRNA and protein levels of Bcl2, which are downregulated by p53, were observed.
The inhibition of Mdm2 by nutlin-3 increased the basal p53 protein level and rescued its tetanization-induced depletion, which suggested the involvement of Mdm2 in the control over p53 during LTP.
Furthermore, nutlin-3 caused an increase in the basal expression of Bax and a decrease in the basal expression of Bcl2, whereas tetanization-induced changes in their expression were occluded.
These results support the hypothesis that p53 may be involved in transcriptional regulation during the early phase of LTP.
We hope that the presented data may aid in the understanding of the contribution of p53 and related genes in the processes that are associated with synaptic plasticity.
American Psychological Association (APA)
Pustylnyak, Vladimir O.& Lisachev, Pavel D.& Shtark, Mark B.. 2015. Expression of p53 Target Genes in the Early Phase of Long-Term Potentiation in the Rat Hippocampal CA1 Area. Neural Plasticity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075309
Modern Language Association (MLA)
Pustylnyak, Vladimir O.…[et al.]. Expression of p53 Target Genes in the Early Phase of Long-Term Potentiation in the Rat Hippocampal CA1 Area. Neural Plasticity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075309
American Medical Association (AMA)
Pustylnyak, Vladimir O.& Lisachev, Pavel D.& Shtark, Mark B.. Expression of p53 Target Genes in the Early Phase of Long-Term Potentiation in the Rat Hippocampal CA1 Area. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075309