PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury
Joint Authors
Song, Juhyun
Cheon, So Yeong
Lee, Won Taek
Park, Kyung Ah
Lee, Jong Eun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The cyclic AMP-dependent protein kinase (PKA), which activates prosurvival signaling proteins, has been implicated in the expression of long-term potentiation and hippocampal long-term memory.
It has come to light that H89 commonly known as the PKA inhibitor have diverse roles in the nervous system that are unrelated to its role as a PKA inhibitor.
We have investigated the role of H89 in ischemic and reperfusion injury.
First, we examined the expression of postsynaptic density protein 95 (PSD95), microtubule-associated protein 2 (MAP2), and synaptophysin in mouse brain after middle cerebral artery occlusion injury.
Next, we examined the role of H89 pretreatment on the expression of brain-derived neurotrophic factor (BDNF), PSD95, MAP2, and the apoptosis regulators Bcl2 and cleaved caspase-3 in cultured neuroblastoma cells exposed to hypoxia and reperfusion injury.
In addition, we investigated the alteration of AKT activation in H89 pretreated neuroblastoma cells under hypoxia and reperfusion injury.
The data suggest that H89 may contribute to brain recovery after ischemic stroke by regulating neuronal death and proteins related to synaptic plasticity.
American Psychological Association (APA)
Song, Juhyun& Cheon, So Yeong& Lee, Won Taek& Park, Kyung Ah& Lee, Jong Eun. 2015. PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury. Neural Plasticity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075330
Modern Language Association (MLA)
Song, Juhyun…[et al.]. PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury. Neural Plasticity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075330
American Medical Association (AMA)
Song, Juhyun& Cheon, So Yeong& Lee, Won Taek& Park, Kyung Ah& Lee, Jong Eun. PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075330