The Morphofunctional Effect of the Transplantation of Bone Marrow Stromal Cells and Predegenerated Peripheral Nerve in Chronic Paraplegic Rat Model via Spinal Cord Transection
Joint Authors
Buzoianu-Anguiano, Vinnitsa
Orozco-Suárez, Sandra
García-Vences, Elisa
Caballero-Chacón, Sara
Guizar-Sahagún, Gabriel
Grijalva, Israel
Chávez-Sánchez, Luis
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Functional recovery following spinal cord injury (SCI) is limited by poor axonal and cellular regeneration as well as the failure to replace damaged myelin.
Employed separately, both the transplantation of the predegenerated peripheral nerve (PPN) and the transplantation of bone marrow stromal cells (BMSCs) have been shown to promote the regrowth and remyelination of the damaged central axons in SCI models of hemisection, transection, and contusion injury.
With the aim to test the effects of the combined transplantation of PPN and BMSC on regrowth, remyelination, and locomotor function in an adult rat model of spinal cord (SC) transection, 39 Fischer 344 rats underwent SC transection at T9 level.
Four weeks later they were randomly assigned to traumatic spinal cord injury (TSCI) without treatment, TSCI + Fibrin Glue (FG), TSCI + FG + PPN, and TSCI + FG + PPN + BMSCs.
Eight weeks after, transplantation was carried out on immunofluorescence and electron microscope studies.
The results showed greater axonal regrowth and remyelination in experimental groups TSCI + FG + PPN and TSCI + FG + PPN + BMSCs analyzed with GAP-43, neuritin, and myelin basic protein.
It is concluded that the combined treatment of PPN and BMSCs is a favorable strategy for axonal regrowth and remyelination in a chronic SC transection model.
American Psychological Association (APA)
Buzoianu-Anguiano, Vinnitsa& Orozco-Suárez, Sandra& García-Vences, Elisa& Caballero-Chacón, Sara& Guizar-Sahagún, Gabriel& Chávez-Sánchez, Luis…[et al.]. 2015. The Morphofunctional Effect of the Transplantation of Bone Marrow Stromal Cells and Predegenerated Peripheral Nerve in Chronic Paraplegic Rat Model via Spinal Cord Transection. Neural Plasticity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075335
Modern Language Association (MLA)
Buzoianu-Anguiano, Vinnitsa…[et al.]. The Morphofunctional Effect of the Transplantation of Bone Marrow Stromal Cells and Predegenerated Peripheral Nerve in Chronic Paraplegic Rat Model via Spinal Cord Transection. Neural Plasticity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075335
American Medical Association (AMA)
Buzoianu-Anguiano, Vinnitsa& Orozco-Suárez, Sandra& García-Vences, Elisa& Caballero-Chacón, Sara& Guizar-Sahagún, Gabriel& Chávez-Sánchez, Luis…[et al.]. The Morphofunctional Effect of the Transplantation of Bone Marrow Stromal Cells and Predegenerated Peripheral Nerve in Chronic Paraplegic Rat Model via Spinal Cord Transection. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075335