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Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat
Joint Authors
Wang, Jian
Feng, Da-Yun
Li, Zhi-Hua
Feng, Ban
Zhang, Han
Zhang, Ting
Chen, Tao
Li, Yun-Qing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The mammalian target of rapamycin (mTOR), a serine-threonine protein kinase, integrates extracellular signals, thereby modulating several physiological and pathological processes, including pain.
Previous studies have suggested that rapamycin (an mTOR inhibitor) can attenuate nociceptive behaviors in many pain models, most likely at the spinal cord level.
However, the mechanisms of mTOR at the supraspinal level, particularly at the level of the rostral ventromedial medulla (RVM), remain unclear.
Thus, the aim of this study was to elucidate the role of mTOR in the RVM, a key relay region for the descending pain control pathway, under neuropathic pain conditions.
Phosphorylated mTOR was mainly expressed in serotonergic spinally projecting neurons and was significantly increased in the RVM after spared nerve injury- (SNI-) induced neuropathic pain.
Moreover, in SNI rat brain slices, rapamycin infusion both decreased the amplitude instead of the frequency of spontaneous excitatory postsynaptic currents and reduced the numbers of action potentials in serotonergic neurons.
Finally, intra-RVM microinjection of rapamycin effectively alleviated established mechanical allodynia but failed to affect the development of neuropathic pain.
In conclusion, our data provide strong evidence for the role of mTOR in the RVM in nerve injury-induced neuropathic pain, indicating a novel mechanism of mTOR inhibitor-induced analgesia.
American Psychological Association (APA)
Wang, Jian& Feng, Da-Yun& Li, Zhi-Hua& Feng, Ban& Zhang, Han& Zhang, Ting…[et al.]. 2015. Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat. Neural Plasticity،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1075339
Modern Language Association (MLA)
Wang, Jian…[et al.]. Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat. Neural Plasticity No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1075339
American Medical Association (AMA)
Wang, Jian& Feng, Da-Yun& Li, Zhi-Hua& Feng, Ban& Zhang, Han& Zhang, Ting…[et al.]. Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1075339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075339