Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices
Joint Authors
Albiñana, Elisa
Gutierrez-Luengo, Javier
Hernández-Juarez, Natalia
Baraibar, Andrés M.
Montell, Eulalia
Vergés, Josep
García, Antonio G.
Hernández-Guijo, Jesus M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
It is currently known that in CNS the extracellular matrix is involved in synaptic stabilization and limitation of synaptic plasticity.
However, it has been reported that the treatment with chondroitinase following injury allows the formation of new synapses and increased plasticity and functional recovery.
So, we hypothesize that some components of extracellular matrix may modulate synaptic transmission.
To test this hypothesis we evaluated the effects of chondroitin sulphate (CS) on excitatory synaptic transmission, cellular excitability, and neuronal plasticity using extracellular recordings in the CA1 area of rat hippocampal slices.
CS caused a reversible depression of evoked field excitatory postsynaptic potentials in a concentration-dependent manner.
CS also reduced the population spike amplitude evoked after orthodromic stimulation but not when the population spikes were antidromically evoked; in this last case a potentiation was observed.
CS also enhanced paired-pulse facilitation and long-term potentiation.
Our study provides evidence that CS, a major component of the brain perineuronal net and extracellular matrix, has a function beyond the structural one, namely, the modulation of synaptic transmission and neuronal plasticity in the hippocampus.
American Psychological Association (APA)
Albiñana, Elisa& Gutierrez-Luengo, Javier& Hernández-Juarez, Natalia& Baraibar, Andrés M.& Montell, Eulalia& Vergés, Josep…[et al.]. 2015. Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices. Neural Plasticity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075351
Modern Language Association (MLA)
Albiñana, Elisa…[et al.]. Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices. Neural Plasticity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075351
American Medical Association (AMA)
Albiñana, Elisa& Gutierrez-Luengo, Javier& Hernández-Juarez, Natalia& Baraibar, Andrés M.& Montell, Eulalia& Vergés, Josep…[et al.]. Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075351