![](/images/graphics-bg.png)
K V 7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons
Joint Authors
Duhne, Mariana
Galarraga, Elvira
Bargas, José
Pérez-Ramírez, M. Belén
Laville, Antonio
Tapia, Dagoberto
Lara-González, Esther
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-31
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Striatal projection neurons (SPNs) process motor and cognitive information.
Their activity is affected by Parkinson’s disease, in which dopamine concentration is decreased and acetylcholine concentration is increased.
Acetylcholine activates muscarinic receptors in SPNs.
Its main source is the cholinergic interneuron that responds with a briefer latency than SPNs during a cortical command.
Therefore, an important question is whether muscarinic G-protein coupled receptors and their signaling cascades are fast enough to intervene during synaptic responses to regulate synaptic integration and firing.
One of the most known voltage dependent channels regulated by muscarinic receptors is the K V 7/KCNQ channel.
It is not known whether these channels regulate the integration of suprathreshold corticostriatal responses.
Here, we study the impact of cholinergic muscarinic modulation on the synaptic response of SPNs by regulating K V 7 channels.
We found that K V 7 channels regulate corticostriatal synaptic integration and that this modulation occurs in the dendritic/spines compartment.
In contrast, it is negligible in the somatic compartment.
This modulation occurs on sub- and suprathreshold responses and lasts during the whole duration of the responses, hundreds of milliseconds, greatly altering SPNs firing properties.
This modulation affected the behavior of the striatal microcircuit.
American Psychological Association (APA)
Pérez-Ramírez, M. Belén& Laville, Antonio& Tapia, Dagoberto& Duhne, Mariana& Lara-González, Esther& Bargas, José…[et al.]. 2015. K V 7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons. Neural Plasticity،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1075354
Modern Language Association (MLA)
Pérez-Ramírez, M. Belén…[et al.]. K V 7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons. Neural Plasticity No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1075354
American Medical Association (AMA)
Pérez-Ramírez, M. Belén& Laville, Antonio& Tapia, Dagoberto& Duhne, Mariana& Lara-González, Esther& Bargas, José…[et al.]. K V 7 Channels Regulate Firing during Synaptic Integration in GABAergic Striatal Neurons. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1075354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075354