Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus
Joint Authors
Salvi, Richard J.
Chen, Yu-Chen
Xia, Wenqing
Li, Xiaowei
Zhang, Jian
Feng, Xu
Wang, Jian
Qian, Cheng
Yang, Xiang-Yu
Lu, Chun-Qiang
Teng, Gao-jun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
Subjective tinnitus is hypothesized to arise from aberrant neural activity; however, its neural bases are poorly understood.
To identify aberrant neural networks involved in chronic tinnitus, we compared the resting-state functional magnetic resonance imaging (fMRI) patterns of tinnitus patients and healthy controls.
Materials and Methods.
Resting-state fMRI measurements were obtained from a group of chronic tinnitus patients ( n = 29 ) with normal hearing and well-matched healthy controls ( n = 30 ).
Regional homogeneity (ReHo) analysis and functional connectivity analysis were used to identify abnormal brain activity; these abnormalities were compared to tinnitus distress.
Results.
Relative to healthy controls, tinnitus patients had significant greater ReHo values in several brain regions including the bilateral anterior insula (AI), left inferior frontal gyrus, and right supramarginal gyrus.
Furthermore, the left AI showed enhanced functional connectivity with the left middle frontal gyrus (MFG), while the right AI had enhanced functional connectivity with the right MFG; these measures were positively correlated with Tinnitus Handicap Questionnaires ( r = 0.459 , P = 0.012 and r = 0.479 , P = 0.009 , resp.).
Conclusions.
Chronic tinnitus patients showed abnormal intra- and interregional synchronization in several resting-state cerebral networks; these abnormalities were correlated with clinical tinnitus distress.
These results suggest that tinnitus distress is exacerbated by attention networks that focus on internally generated phantom sounds.
American Psychological Association (APA)
Chen, Yu-Chen& Zhang, Jian& Li, Xiaowei& Xia, Wenqing& Feng, Xu& Qian, Cheng…[et al.]. 2015. Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus. Neural Plasticity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075356
Modern Language Association (MLA)
Chen, Yu-Chen…[et al.]. Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus. Neural Plasticity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075356
American Medical Association (AMA)
Chen, Yu-Chen& Zhang, Jian& Li, Xiaowei& Xia, Wenqing& Feng, Xu& Qian, Cheng…[et al.]. Altered Intra- and Interregional Synchronization in Resting-State Cerebral Networks Associated with Chronic Tinnitus. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075356