Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine
Joint Authors
Pfeilschifter, Josef
Brunkhorst, R.
Friedlaender, F.
Ferreirós, N.
Schwalm, S.
Koch, A.
Grammatikos, G.
Toennes, S.
Foerch, C.
Pfeilschifter, W.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ceramides induce important intracellular signaling pathways, modulating proliferation, migration, apoptosis, and inflammation.
However, the relevance of the ceramide metabolism in the reconvalescence phase after stroke is unclear.
Besides its well-known property as a selective serotonin reuptake inhibitor, fluoxetine has been reported to inhibit the acid sphingomyelinase (ASM), a key regulator of ceramide levels which derives ceramide from sphingomyelin.
Furthermore, fluoxetine has shown therapeutic potential in a randomized controlled rehabilitation trial in stroke patients.
Our aim was to investigate and modulate ceramide concentrations in the peri-infarct cortex, whose morphological and functional properties correlate with long-term functional outcome in stroke.
We show that certain ceramide species are modulated after experimental stroke and that these changes do not result from alterations of ASM activity, but rather from nontranscriptional induction of the ceramide de novo pathway.
Unexpectedly, although reducing lesion size, fluoxetine did not improve functional outcome in our model and had no significant influence on ASM activity or the concentration of ceramides.
The ceramide metabolism could emerge as a potential therapeutic target in the reconvalescence phase after stroke, as its accumulation in the peri-infarct cortex potentially influences membrane functions as well as signaling events in the tissue essential for neurological recovery.
American Psychological Association (APA)
Brunkhorst, R.& Friedlaender, F.& Ferreirós, N.& Schwalm, S.& Koch, A.& Grammatikos, G.…[et al.]. 2015. Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine. Neural Plasticity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075358
Modern Language Association (MLA)
Brunkhorst, R.…[et al.]. Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine. Neural Plasticity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075358
American Medical Association (AMA)
Brunkhorst, R.& Friedlaender, F.& Ferreirós, N.& Schwalm, S.& Koch, A.& Grammatikos, G.…[et al.]. Alterations of the Ceramide Metabolism in the Peri-Infarct Cortex Are Independent of the Sphingomyelinase Pathway and Not Influenced by the Acid Sphingomyelinase Inhibitor Fluoxetine. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075358
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075358