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Diverse Short-Term Dynamics of Inhibitory Synapses Converging on Striatal Projection Neurons: Differential Changes in a Rodent Model of Parkinson’s Disease
Joint Authors
Barroso-Flores, Janet
Galarraga, Elvira
Bargas, José
Herrera-Valdez, Marco A.
Lopez-Huerta, Violeta Gisselle
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Most neurons in the striatum are projection neurons (SPNs) which make synapses with each other within distances of approximately 100 µm.
About 5% of striatal neurons are GABAergic interneurons whose axons expand hundreds of microns.
Short-term synaptic plasticity (STSP) between fast-spiking (FS) interneurons and SPNs and between SPNs has been described with electrophysiological and optogenetic techniques.
It is difficult to obtain pair recordings from some classes of interneurons and due to limitations of actual techniques, no other types of STSP have been described on SPNs.
Diverse STSPs may reflect differences in presynaptic release machineries.
Therefore, we focused the present work on answering two questions: Are there different identifiable classes of STSP between GABAergic synapses on SPNs? And, if so, are synapses exhibiting different classes of STSP differentially affected by dopamine depletion? Whole-cell voltage-clamp recordings on SPNs revealed three classes of STSPs: depressing, facilitating, and biphasic (facilitating-depressing), in response to stimulation trains at 20 Hz, in a constant ionic environment.
We then used the 6-hydroxydopamine (6-OHDA) rodent model of Parkinson’s disease to show that synapses with different STSPs are differentially affected by dopamine depletion.
We propose a general model of STSP that fits all the dynamics found in our recordings.
American Psychological Association (APA)
Barroso-Flores, Janet& Herrera-Valdez, Marco A.& Lopez-Huerta, Violeta Gisselle& Galarraga, Elvira& Bargas, José. 2015. Diverse Short-Term Dynamics of Inhibitory Synapses Converging on Striatal Projection Neurons: Differential Changes in a Rodent Model of Parkinson’s Disease. Neural Plasticity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075366
Modern Language Association (MLA)
Barroso-Flores, Janet…[et al.]. Diverse Short-Term Dynamics of Inhibitory Synapses Converging on Striatal Projection Neurons: Differential Changes in a Rodent Model of Parkinson’s Disease. Neural Plasticity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075366
American Medical Association (AMA)
Barroso-Flores, Janet& Herrera-Valdez, Marco A.& Lopez-Huerta, Violeta Gisselle& Galarraga, Elvira& Bargas, José. Diverse Short-Term Dynamics of Inhibitory Synapses Converging on Striatal Projection Neurons: Differential Changes in a Rodent Model of Parkinson’s Disease. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075366