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Complex Inflammation mRNA-Related Response in ALS Is Region Dependent
Joint Authors
Povedano, Mònica
Berjaoui, Sara
Garcia-Esparcia, Paula
Carmona, Margarita
Aso, Ester
Ferrer, Isidro
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Inflammatory changes are analyzed in the anterior spinal cord and frontal cortex area 8 in typical spinal-predominant ALS cases.
Increased numbers of astrocytes and activated microglia are found in the anterior horn of the spinal cord and pyramidal tracts.
Significant increased expression of TLR7, CTSS, and CTSC mRNA and a trend to increased expression of IL10RA, TGFB1, and TGFB2 are found in the anterior lumbar spinal cord in ALS cases compared to control cases, whereas C1QTNF7 and TNFRSF1A mRNA expression levels are significantly decreased.
IL6 is significantly upregulated and IL1B shows a nonsignificant increased expression in frontal cortex area 8 in ALS cases.
IL-6 immunoreactivity is found in scattered monocyte-derived macrophages/microglia and TNF-α in a few cells of unknown origin in ALS cases.
Increased expression and abnormal distribution of IL-1β occurred in motor neurons of the lumbar spinal cord in ALS.
Strong IL-10 immunoreactivity colocalizes with TDP-43-positive inclusions in motor neurons in ALS cases.
The present observations show a complex participation of cytokines and mediators of the inflammatory response in ALS consistent with increased proinflammatory cytokines and sequestration of anti-inflammatory IL-10 in affected neurons.
American Psychological Association (APA)
Berjaoui, Sara& Povedano, Mònica& Garcia-Esparcia, Paula& Carmona, Margarita& Aso, Ester& Ferrer, Isidro. 2015. Complex Inflammation mRNA-Related Response in ALS Is Region Dependent. Neural Plasticity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075367
Modern Language Association (MLA)
Berjaoui, Sara…[et al.]. Complex Inflammation mRNA-Related Response in ALS Is Region Dependent. Neural Plasticity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075367
American Medical Association (AMA)
Berjaoui, Sara& Povedano, Mònica& Garcia-Esparcia, Paula& Carmona, Margarita& Aso, Ester& Ferrer, Isidro. Complex Inflammation mRNA-Related Response in ALS Is Region Dependent. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075367