![](/images/graphics-bg.png)
Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress
Joint Authors
Machado-Vieira, Rodrigo
Gold, Phillip W.
Pavlatou, Maria G.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Major depressive disorder (MDD) is a chronic, recurrent, and severe psychiatric disorder with high mortality and medical comorbidities.
Stress-related pathways have been directly involved in the pathophysiology and treatment of MDD.
The present paper provides an overview on the stress system as a model to understand key pathophysiological paradigms in MDD.
These mechanisms involve behavioral, cognitive, and systemic manifestations and are also associated with the mechanisms of action of effective antidepressants.
Aspects such as depression subtypes, inflammation, insulin resistance, oxidative stress, and prothrombotic states in critical brain circuits and periphery are critically appraised.
Finally, new strategies for approaching treatment-resistant major depression and potential adverse effects associated with this complex and intricate network are highlighted.
The authors used PubMed as the database for this review.
Each author extracted relevant data and assessed the methodological quality of each study.
American Psychological Association (APA)
Gold, Phillip W.& Machado-Vieira, Rodrigo& Pavlatou, Maria G.. 2015. Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress. Neural Plasticity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075369
Modern Language Association (MLA)
Gold, Phillip W.…[et al.]. Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress. Neural Plasticity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075369
American Medical Association (AMA)
Gold, Phillip W.& Machado-Vieira, Rodrigo& Pavlatou, Maria G.. Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075369