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Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage
Joint Authors
Tomaiuolo, Micol
Katche, Cynthia
Viola, Haydee
Medina, Jorge H.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation.
Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism.
Here we show that a maintenance tagging process may operate in the hippocampus late after acquisition for the persistence of long-lasting memory storage.
The proposed maintenance tagging has several characteristics: (1) the tag is transient and time-dependent; (2) it sets in a late critical time window after an aversive training which induces a short-lasting LTM; (3) exposing rats to a novel environment specifically within this tag time window enables the consolidation to a long-lasting LTM; (4) a familiar environment exploration was not effective; (5) the effect of novelty on the promotion of memory persistence requires dopamine D1/D5 receptors and Arc expression in the dorsal hippocampus.
The present results can be explained by a broader version of the behavioral tagging hypothesis and highlight the idea that the durability of a memory trace depends either on late tag mechanisms induced by a training session or on events experienced close in time to this tag.
American Psychological Association (APA)
Tomaiuolo, Micol& Katche, Cynthia& Viola, Haydee& Medina, Jorge H.. 2015. Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage. Neural Plasticity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075375
Modern Language Association (MLA)
Tomaiuolo, Micol…[et al.]. Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage. Neural Plasticity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075375
American Medical Association (AMA)
Tomaiuolo, Micol& Katche, Cynthia& Viola, Haydee& Medina, Jorge H.. Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075375