Neurophysiological Correlates of Central Fatigue in Healthy Subjects and Multiple Sclerosis Patients before and after Treatment with Amantadine
Joint Authors
Santarnecchi, Emiliano
Rossi, Simone
Bartalini, Sabina
Cincotta, Massimo
Giovannelli, Fabio
Tatti, Elisa
Ulivelli, Monica
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In ten healthy subjects and in ten patients suffering from Multiple Sclerosis (MS), we investigated the cortical functional changes induced by a standard fatiguing repetitive tapping task.
The Cortical Silent Period (CSP), an intracortical, mainly GABAB-mediated inhibitory phenomenon, was recorded by two different hand muscles, one acting as prime mover of the fatiguing index-thumb tapping task (First Dorsal Interosseous, FDI) and the other one not involved in the task but sharing largely overlapping central, spinal, and peripheral innervation (Abductor Digiti Minimi, ADM).
At baseline, the CSP was shorter in patients than in controls.
As fatigue developed, CSP changes involved both the “fatigued” FDI and the “unfatigued” ADM muscles, suggesting a cortical spread of central fatigue mechanisms.
Chronic therapy with amantadine annulled differences in CSP duration between controls and patients, possibly through restoration of more physiological levels of intracortical inhibition in the motor cortex.
These inhibitory changes correlated with the improvement of fatigue scales.
The CSP may represent a suitable marker of neurophysiological mechanisms accounting for central fatigue generation either in controls or in MS patients, involving corticospinal neural pools supplying not only the fatigued muscle but also adjacent muscles sharing an overlapping cortical representation.
American Psychological Association (APA)
Santarnecchi, Emiliano& Rossi, Simone& Bartalini, Sabina& Cincotta, Massimo& Giovannelli, Fabio& Tatti, Elisa…[et al.]. 2015. Neurophysiological Correlates of Central Fatigue in Healthy Subjects and Multiple Sclerosis Patients before and after Treatment with Amantadine. Neural Plasticity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075378
Modern Language Association (MLA)
Santarnecchi, Emiliano…[et al.]. Neurophysiological Correlates of Central Fatigue in Healthy Subjects and Multiple Sclerosis Patients before and after Treatment with Amantadine. Neural Plasticity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075378
American Medical Association (AMA)
Santarnecchi, Emiliano& Rossi, Simone& Bartalini, Sabina& Cincotta, Massimo& Giovannelli, Fabio& Tatti, Elisa…[et al.]. Neurophysiological Correlates of Central Fatigue in Healthy Subjects and Multiple Sclerosis Patients before and after Treatment with Amantadine. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075378