Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL6N Mice
Joint Authors
Wang, Zhongli
Bian, Yaoyao
Yang, Lili
Wang, Qing
Zeng, Li
Xu, Guihua
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Adverse early life experiences can negatively affect behaviors later in life.
Maternal separation (MS) has been extensively investigated in animal models in the adult phase of MS.
The study aimed to explore the mechanism by which MS negatively affects C57BL/6N mice, especially the effects caused by MS in the early phase.
Early life adversity especially can alter plasticity functions.
To determine whether adverse early life experiences induce changes in plasticity in the brain hippocampus, we established an MS paradigm.
In this research, the mice were treated with mild (15 min, MS15) or prolonged (180 min, MS180) maternal separation from postnatal day 2 to postnatal day 21.
The mice underwent a forced swimming test, a tail suspension test, and an open field test, respectively.
Afterward, the mice were sacrificed on postnatal day 31 to determine the effects of MS on early life stages.
Results implied that MS induces depression-like behavior and the effects may be mediated partly by interfering with the hippocampal GSK-3β-CREB signaling pathway and by reducing the levels of some plasticity-related proteins.
American Psychological Association (APA)
Bian, Yaoyao& Yang, Lili& Wang, Zhongli& Wang, Qing& Zeng, Li& Xu, Guihua. 2015. Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL6N Mice. Neural Plasticity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075379
Modern Language Association (MLA)
Bian, Yaoyao…[et al.]. Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL6N Mice. Neural Plasticity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075379
American Medical Association (AMA)
Bian, Yaoyao& Yang, Lili& Wang, Zhongli& Wang, Qing& Zeng, Li& Xu, Guihua. Repeated Three-Hour Maternal Separation Induces Depression-Like Behavior and Affects the Expression of Hippocampal Plasticity-Related Proteins in C57BL6N Mice. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075379