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CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex
Joint Authors
Pignataro, Annabella
Borreca, Antonella
Ammassari-Teule, Martine
Middei, Silvia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Experience modifies synaptic connectivity through processes that involve dendritic spine rearrangements in neuronal circuits.
Although cAMP response element binding protein (CREB) has a key function in spines changes, its role in activity-dependent rearrangements in brain regions of rodents interacting with the surrounding environment has received little attention so far.
Here we studied the effects of vibrissae trimming, a widely used model of sensory deprivation-induced cortical plasticity, on processes associated with dendritic spine rearrangements in the barrel cortex of a transgenic mouse model of CREB downregulation (mCREB mice).
We found that sensory deprivation through prolonged whisker trimming leads to an increased number of thin spines in the layer V of related barrel cortex (Contra) in wild type but not mCREB mice.
In the barrel field controlling spared whiskers (Ipsi), the same trimming protocol results in a CREB-dependent enlargement of dendritic spines.
Last, we demonstrated that CREB regulates structural rearrangements of synapses that associate with dynamic changes of dendritic spines.
Our findings suggest that CREB plays a key role in dendritic spine dynamics and synaptic circuits rearrangements that account for new brain connectivity in response to changes in the environment.
American Psychological Association (APA)
Pignataro, Annabella& Borreca, Antonella& Ammassari-Teule, Martine& Middei, Silvia. 2015. CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex. Neural Plasticity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075383
Modern Language Association (MLA)
Pignataro, Annabella…[et al.]. CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex. Neural Plasticity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075383
American Medical Association (AMA)
Pignataro, Annabella& Borreca, Antonella& Ammassari-Teule, Martine& Middei, Silvia. CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075383