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Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila
Joint Authors
Campusano, Jorge M.
Silva, Bryon
Molina-Fernández, Claudia
Ugalde, María Beatriz
Tognarelli, Eduardo I.
Angel, Cristian
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The most studied form of associative learning in Drosophila consists in pairing an odorant, the conditioned stimulus (CS), with an unconditioned stimulus (US).
The timely arrival of the CS and US information to a specific Drosophila brain association region, the mushroom bodies (MB), can induce new olfactory memories.
Thus, the MB is considered a coincidence detector.
It has been shown that olfactory information is conveyed to the MB through cholinergic inputs that activate acetylcholine (ACh) receptors, while the US is encoded by biogenic amine (BA) systems.
In recent years, we have advanced our understanding on the specific neural BA pathways and receptors involved in olfactory learning and memory.
However, little information exists on the contribution of cholinergic receptors to this process.
Here we evaluate for the first time the proposition that, as in mammals, muscarinic ACh receptors (mAChRs) contribute to memory formation in Drosophila.
Our results show that pharmacological and genetic blockade of mAChRs in MB disrupts olfactory aversive memory in larvae.
This effect is not explained by an alteration in the ability of animals to respond to odorants or to execute motor programs.
These results show that mAChRs in MB contribute to generating olfactory memories in Drosophila.
American Psychological Association (APA)
Silva, Bryon& Molina-Fernández, Claudia& Ugalde, María Beatriz& Tognarelli, Eduardo I.& Angel, Cristian& Campusano, Jorge M.. 2015. Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila. Neural Plasticity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075387
Modern Language Association (MLA)
Silva, Bryon…[et al.]. Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila. Neural Plasticity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075387
American Medical Association (AMA)
Silva, Bryon& Molina-Fernández, Claudia& Ugalde, María Beatriz& Tognarelli, Eduardo I.& Angel, Cristian& Campusano, Jorge M.. Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075387