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Preclinical Evidences for an Antimanic Effect of Carvedilol
Joint Authors
Quevedo, João
de Souza, Greicy Coelho
Gomes, Julia Ariana de S.
de Góis Queiroz, Ana Isabelle
de Araújo, Maíra Morais
Cavalcante, Lígia Menezes
Machado, Michel de Jesus Souza
Monte, Aline Santos
de Lucena, David Freitas
Carvalho, André Ferrer
Macêdo, Danielle
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oxidative imbalance, alterations in brain-derived neurotrophic factor (BDNF), and mitochondrial dysfunction are implicated in bipolar disorder (BD) pathophysiology and comorbidities, for example, cardiovascular conditions.
Carvedilol (CVD), a nonselective beta-blocker widely used for the treatment of hypertension, presents antioxidant and mitochondrial stabilizing properties.
Thus, we hypothesized that CVD would prevent and/or reverse mania-like behavioral and neurochemical alterations induced by lisdexamfetamine dimesylate (LDX).
To do this, male Wistar rats were submitted to two different protocols, namely, prevention and reversal.
In the prevention treatment the rats received daily oral administration (mg/kg) of CVD (2.5, 5 or 7.5), saline, valproate (VAL200), or the combination of CVD5 + VAL100 for 7 days.
From the 8th to 14th day LDX was added.
In the reversal protocol LDX was administered for 7 days with the drugs being added from the 8th to 14th day of treatment.
Two hours after the last administration the behavioral (open field and social interaction) and neurochemical (reduced glutathione, lipid peroxidation, and BDNF) determinations were performed.
The results showed that CVD prevented and reversed the behavioral and neurochemical alterations induced by LDX.
The administration of CVD5 + VAL100 potentiated the effect of VAL200 alone.
Taken together these results demonstrate a possible antimanic effect of CVD in this preclinical model.
American Psychological Association (APA)
de Souza, Greicy Coelho& Gomes, Julia Ariana de S.& de Góis Queiroz, Ana Isabelle& de Araújo, Maíra Morais& Cavalcante, Lígia Menezes& Machado, Michel de Jesus Souza…[et al.]. 2015. Preclinical Evidences for an Antimanic Effect of Carvedilol. Neural Plasticity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075394
Modern Language Association (MLA)
de Souza, Greicy Coelho…[et al.]. Preclinical Evidences for an Antimanic Effect of Carvedilol. Neural Plasticity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075394
American Medical Association (AMA)
de Souza, Greicy Coelho& Gomes, Julia Ariana de S.& de Góis Queiroz, Ana Isabelle& de Araújo, Maíra Morais& Cavalcante, Lígia Menezes& Machado, Michel de Jesus Souza…[et al.]. Preclinical Evidences for an Antimanic Effect of Carvedilol. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075394