A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain
Joint Authors
Han, Wenjuan
Chen, Lei
Wang, Hai-Bo
Liu, Xiang-Zeng
Sun, Xiao-Li
Luo, Ceng
Hu, Sanjue
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Evidence has accumulated that reactive oxygen species and inflammation play crucial roles in the development of chronic pain, including radicular low back pain.
Nonsteroid anti-inflammatory drugs (NSAIDs), for example, salicylic acid, aspirin, provided analgesic effects in various types of pain.
However, long-term use of these drugs causes unwanted side effects, which limits their implication.
Stable nitronyl (NIT) nitroxide radicals have been extensively studied as a unique and interesting class of new antioxidants for protection against oxidative damage.
The present study synthesized a novel NIT nitroxide radical with salicylic acid framework (SANR) to provide synergistic effect of both antioxidation and antiinflammation.
We demonstrated for the first time that both acute and repeated SANR treatment exerted dramatic analgesic effect in radicular low back pain mimicked by chronic compression of dorsal root ganglion in rats.
This analgesic potency was more potent than that produced by classical NSAIDs aspirin and traditional nitroxide radical Tempol alone.
Furthermore, SANR-induced behavioral analgesia is found to be mediated, at least in partial, by a reduction of ectopic spontaneous discharges in injured DRG neurons.
Therefore, the synthesized NIT nitroxide radical coupling with salicylic acid framework may represent a novel potential therapeutic candidate for treatment of chronic pain, including radicular low back pain.
American Psychological Association (APA)
Han, Wenjuan& Chen, Lei& Wang, Hai-Bo& Liu, Xiang-Zeng& Hu, Sanjue& Sun, Xiao-Li…[et al.]. 2015. A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain. Neural Plasticity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075402
Modern Language Association (MLA)
Han, Wenjuan…[et al.]. A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain. Neural Plasticity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075402
American Medical Association (AMA)
Han, Wenjuan& Chen, Lei& Wang, Hai-Bo& Liu, Xiang-Zeng& Hu, Sanjue& Sun, Xiao-Li…[et al.]. A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075402