Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target?
Joint Authors
Alves, Gilberto Sousa
Carvalho, André Férrer
Köhler, Cristiano A.
McIntyre, Roger S.
Cammarota, Martín
Hyphantis, T.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Major depressive disorder (MDD) is characterized by a dysfunctional processing of autobiographical memories.
We review the following core domains of deficit: systematic biases favoring materials of negative emotional valence; diminished access and response to positive memories; a recollection of overgeneral memories in detriment of specific autobiographical memories; and the role of ruminative processes and avoidance when dealing with autobiographical memories.
Furthermore, we review evidence from functional neuroimaging studies of neural circuits activated by the recollection of autobiographical memories in both healthy and depressive individuals.
Disruptions in autobiographical memories predispose and portend onset and maintenance of depression.
Thus, we discuss emerging therapeutics that target memory difficulties in those with depression.
We review strategies for this clinical domain, including memory specificity training, method-of-loci, memory rescripting, and real-time fMRI neurofeedback training of amygdala activity in depression.
We propose that the manipulation of the reconsolidation of autobiographical memories in depression might represent a novel yet largely unexplored, domain-specific, therapeutic opportunity for depression treatment.
American Psychological Association (APA)
Köhler, Cristiano A.& Carvalho, André Férrer& Alves, Gilberto Sousa& McIntyre, Roger S.& Hyphantis, T.& Cammarota, Martín. 2015. Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target?. Neural Plasticity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075405
Modern Language Association (MLA)
Köhler, Cristiano A.…[et al.]. Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target?. Neural Plasticity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075405
American Medical Association (AMA)
Köhler, Cristiano A.& Carvalho, André Férrer& Alves, Gilberto Sousa& McIntyre, Roger S.& Hyphantis, T.& Cammarota, Martín. Autobiographical Memory Disturbances in Depression: A Novel Therapeutic Target?. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075405