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Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Corticobasal ganglia networks coursing through the striatum are key structures for reward-guided behaviors.
The ventral striatum (nucleus accumbens (nAc)) and its reciprocal connection with the ventral tegmental area (VTA) represent a primary component of the reward system, but reward-guided learning also involves the dorsal striatum and dopaminergic inputs from the substantia nigra.
The majority of neurons in the striatum (>90%) are GABAergic medium spiny neurons (MSNs), but both the input to and the output from these neurons are dynamically controlled by striatal interneurons.
Dopamine is a key neurotransmitter in reward and reward-guided learning, and the physiological activity of GABAergic and cholinergic interneurons is regulated by dopaminergic transmission in a complex manner.
Here we review the role of striatal interneurons in modulating striatal output during drug reward, with special emphasis on alcohol.
American Psychological Association (APA)
Clarke, Rhona& Adermark, Louise. 2015. Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol. Neural Plasticity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075412
Modern Language Association (MLA)
Clarke, Rhona& Adermark, Louise. Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol. Neural Plasticity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075412
American Medical Association (AMA)
Clarke, Rhona& Adermark, Louise. Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075412