The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation
Joint Authors
Zhao, Lu
Evans, Alan C.
Jiang, Guangyao
Yin, Xuntao
Li, Chuanming
Li, Lei
Wu, Jixiang
Wang, Jian
Jiang, Tianzi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Accumulating evidence has indicated that amputation induces functional reorganization in the sensory and motor cortices.
However, the extent of structural changes after lower limb amputation in patients without phantom pain remains uncertain.
We studied 17 adult patients with right lower limb amputation and 18 healthy control subjects using T1-weighted magnetic resonance imaging and diffusion tensor imaging.
Cortical thickness and fractional anisotropy (FA) of white matter (WM) were investigated.
In amputees, a thinning trend was seen in the left premotor cortex (PMC).
Smaller clusters were also noted in the visual-to-motor regions.
In addition, the amputees also exhibited a decreased FA in the right superior corona radiata and WM regions underlying the right temporal lobe and left PMC.
Fiber tractography from these WM regions showed microstructural changes in the commissural fibers connecting the bilateral premotor cortices, compatible with the hypothesis that amputation can lead to a change in interhemispheric interactions.
Finally, the lower limb amputees also displayed significant FA reduction in the right inferior frontooccipital fasciculus, which is negatively correlated with the time since amputation.
In conclusion, our findings indicate that the amputation of lower limb could induce changes in the cortical representation of the missing limb and the underlying WM connections.
American Psychological Association (APA)
Jiang, Guangyao& Yin, Xuntao& Li, Chuanming& Li, Lei& Zhao, Lu& Evans, Alan C.…[et al.]. 2015. The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation. Neural Plasticity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075414
Modern Language Association (MLA)
Jiang, Guangyao…[et al.]. The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation. Neural Plasticity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075414
American Medical Association (AMA)
Jiang, Guangyao& Yin, Xuntao& Li, Chuanming& Li, Lei& Zhao, Lu& Evans, Alan C.…[et al.]. The Plasticity of Brain Gray Matter and White Matter following Lower Limb Amputation. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075414