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Hippocampal Infusion of Zeta Inhibitory Peptide Impairs Recent, but Not Remote, Recognition Memory in Rats
Joint Authors
Hales, Jena B.
Ocampo, Amber C.
Broadbent, Nicola J.
Clark, Robert E.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Spatial memory in rodents can be erased following the infusion of zeta inhibitory peptide (ZIP) into the dorsal hippocampus via indwelling guide cannulas.
It is believed that ZIP impairs spatial memory by reversing established late-phase long-term potentiation (LTP).
However, it is unclear whether other forms of hippocampus-dependent memory, such as recognition memory, are also supported by hippocampal LTP.
In the current study, we tested recognition memory in rats following hippocampal ZIP infusion.
In order to combat the limited targeting of infusions via cannula, we implemented a stereotaxic approach for infusing ZIP throughout the dorsal, intermediate, and ventral hippocampus.
Rats infused with ZIP 3–7 days after training on the novel object recognition task exhibited impaired object recognition memory compared to control rats (those infused with aCSF).
In contrast, rats infused with ZIP 1 month after training performed similar to control rats.
The ability to form new memories after ZIP infusions remained intact.
We suggest that enhanced recognition memory for recent events is supported by hippocampal LTP, which can be reversed by hippocampal ZIP infusion.
American Psychological Association (APA)
Hales, Jena B.& Ocampo, Amber C.& Broadbent, Nicola J.& Clark, Robert E.. 2015. Hippocampal Infusion of Zeta Inhibitory Peptide Impairs Recent, but Not Remote, Recognition Memory in Rats. Neural Plasticity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075419
Modern Language Association (MLA)
Hales, Jena B.…[et al.]. Hippocampal Infusion of Zeta Inhibitory Peptide Impairs Recent, but Not Remote, Recognition Memory in Rats. Neural Plasticity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075419
American Medical Association (AMA)
Hales, Jena B.& Ocampo, Amber C.& Broadbent, Nicola J.& Clark, Robert E.. Hippocampal Infusion of Zeta Inhibitory Peptide Impairs Recent, but Not Remote, Recognition Memory in Rats. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075419