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Generation of New Neurons in Dorsal Root Ganglia in Adult Rats after Peripheral Nerve Crush Injury
Joint Authors
Muratori, Luisa
Giacobini-Robecchi, Maria Giuseppina
Fornaro, Michele
Geuna, Stefano
Raimondo, Stefania
Ronchi, Giulia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The evidence of neurons generated ex novo in sensory ganglia of adult animals is still debated.
In the present study, we investigated, using high resolution light microscopy and stereological analysis, the changes in the number of neurons in dorsal root ganglia after 30 days from a crush lesion of the rat brachial plexus terminal branches.
Results showed, as expected, a relevant hypertrophy of dorsal root ganglion neurons.
In addition, we reported, for the first time in the literature, that neuronal hypertrophy was accompanied by massive neuronal hyperplasia leading to a 42% increase of the number of primary sensory neurons.
Moreover, ultrastructural analyses on sensory neurons showed that there was not a relevant neuronal loss as a consequence of the nerve injury.
The evidence of BrdU-immunopositive neurons and neural progenitors labeled with Ki67, nanog, nestin, and sox-2 confirmed the stereological evidence of posttraumatic neurogenesis in dorsal root ganglia.
Analysis of morphological changes following axonal damage in addition to immunofluorescence characterization of cell phenotype suggested that the neuronal precursors which give rise to the newly generated neurons could be represented by satellite glial cells that actively proliferate after the lesion and are able to differentiate toward the neuronal lineage.
American Psychological Association (APA)
Muratori, Luisa& Ronchi, Giulia& Raimondo, Stefania& Geuna, Stefano& Giacobini-Robecchi, Maria Giuseppina& Fornaro, Michele. 2015. Generation of New Neurons in Dorsal Root Ganglia in Adult Rats after Peripheral Nerve Crush Injury. Neural Plasticity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075421
Modern Language Association (MLA)
Muratori, Luisa…[et al.]. Generation of New Neurons in Dorsal Root Ganglia in Adult Rats after Peripheral Nerve Crush Injury. Neural Plasticity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075421
American Medical Association (AMA)
Muratori, Luisa& Ronchi, Giulia& Raimondo, Stefania& Geuna, Stefano& Giacobini-Robecchi, Maria Giuseppina& Fornaro, Michele. Generation of New Neurons in Dorsal Root Ganglia in Adult Rats after Peripheral Nerve Crush Injury. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075421