![](/images/graphics-bg.png)
Cordycepin Decreases Compound Action Potential Conduction of Frog Sciatic Nerve In Vitro Involving Ca2+-Dependent Mechanisms
Joint Authors
Yao, Li-Hua
Yu, Hui-Min
Xiong, Qiu-Ping
Sun, Wei
Xu, Yan-Liang
Meng, Wei
Li, Yu-Ping
Liu, Xin-Ping
Yuan, Chun-Hua
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cordycepin has been widely used in oriental countries to maintain health and improve physical performance.
Compound nerve action potential (CNAP), which is critical in signal conduction in the peripheral nervous system, is necessary to regulate physical performance, including motor system physiological and pathological processes.
Therefore, regulatory effects of cordycepin on CNAP conduction should be elucidated.
In this study, the conduction ability of CNAP in isolated frog sciatic nerves was investigated.
Results revealed that cordycepin significantly decreased CNAP amplitude and conductive velocity in a reversible and concentration-dependent manner.
At 50 mg/L cordycepin, CNAP amplitude and conductive velocity decreased by 62.18 ± 8.06% and 57.34% ± 6.14% compared with the control amplitude and conductive velocity, respectively.
However, the depressive action of cordycepin on amplitude and conductive velocity was not observed in Ca2+-free medium or in the presence of Ca2+ channel blockers (CdCl2/LaCl3).
Pretreatment with L-type Ca2+ channel antagonist (nifedipine/deltiazem) also blocked cordycepin-induced responses; by contrast, T-type and P-type Ca2+ channel antagonists (Ni2+) failed to block such responses.
Therefore, cordycepin decreased the conduction ability of CNAP in isolated frog sciatic nerves via L-type Ca2+ channel-dependent mechanism.
American Psychological Association (APA)
Yao, Li-Hua& Yu, Hui-Min& Xiong, Qiu-Ping& Sun, Wei& Xu, Yan-Liang& Meng, Wei…[et al.]. 2015. Cordycepin Decreases Compound Action Potential Conduction of Frog Sciatic Nerve In Vitro Involving Ca2+-Dependent Mechanisms. Neural Plasticity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075427
Modern Language Association (MLA)
Yao, Li-Hua…[et al.]. Cordycepin Decreases Compound Action Potential Conduction of Frog Sciatic Nerve In Vitro Involving Ca2+-Dependent Mechanisms. Neural Plasticity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075427
American Medical Association (AMA)
Yao, Li-Hua& Yu, Hui-Min& Xiong, Qiu-Ping& Sun, Wei& Xu, Yan-Liang& Meng, Wei…[et al.]. Cordycepin Decreases Compound Action Potential Conduction of Frog Sciatic Nerve In Vitro Involving Ca2+-Dependent Mechanisms. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075427