Andrographolide Stimulates Neurogenesis in the Adult Hippocampus
Joint Authors
Tapia-Rojas, Cheril
Varela-Nallar, Lorena
Arredondo, Sebastian B.
Hancke, Juan
Inestrosa, Nibaldo C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Andrographolide (ANDRO) is a labdane diterpenoid component of Andrographis paniculata widely used for its anti-inflammatory properties.
We have recently determined that ANDRO is a competitive inhibitor of glycogen synthase kinase-3β (GSK-3β), a key enzyme of the Wnt/β-catenin signaling cascade.
Since this signaling pathway regulates neurogenesis in the adult hippocampus, we evaluated whether ANDRO stimulates this process.
Treatment with ANDRO increased neural progenitor cell proliferation and the number of immature neurons in the hippocampus of 2- and 10-month-old mice compared to age-matched control mice.
Moreover, ANDRO stimulated neurogenesis increasing the number of newborn dentate granule neurons.
Also, the effect of ANDRO was evaluated in the APPswe/PS1ΔE9 transgenic mouse model of Alzheimer’s disease.
In these mice, ANDRO increased cell proliferation and the density of immature neurons in the dentate gyrus.
Concomitantly with the increase in neurogenesis, ANDRO induced the activation of the Wnt signaling pathway in the hippocampus of wild-type and APPswe/PS1ΔE9 mice determined by increased levels of β-catenin, the inactive form of GSK-3β, and NeuroD1, a Wnt target gene involved in neurogenesis.
Our findings indicate that ANDRO stimulates neurogenesis in the adult hippocampus suggesting that this drug could be used as a therapy in diseases in which neurogenesis is affected.
American Psychological Association (APA)
Varela-Nallar, Lorena& Arredondo, Sebastian B.& Tapia-Rojas, Cheril& Hancke, Juan& Inestrosa, Nibaldo C.. 2015. Andrographolide Stimulates Neurogenesis in the Adult Hippocampus. Neural Plasticity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075428
Modern Language Association (MLA)
Varela-Nallar, Lorena…[et al.]. Andrographolide Stimulates Neurogenesis in the Adult Hippocampus. Neural Plasticity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075428
American Medical Association (AMA)
Varela-Nallar, Lorena& Arredondo, Sebastian B.& Tapia-Rojas, Cheril& Hancke, Juan& Inestrosa, Nibaldo C.. Andrographolide Stimulates Neurogenesis in the Adult Hippocampus. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075428