Zinc in Gut-Brain Interaction in Autism and Neurological Disorders
Joint Authors
Vela, Guillermo
Stark, Peter
Socha, Michael
Sauer, Ann Katrin
Hagmeyer, Simone
Grabrucker, Andreas M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-23
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
A growing amount of research indicates that abnormalities in the gastrointestinal (GI) system during development might be a common factor in multiple neurological disorders and might be responsible for some of the shared comorbidities seen among these diseases.
For example, many patients with Autism Spectrum Disorder (ASD) have symptoms associated with GI disorders.
Maternal zinc status may be an important factor given the multifaceted effect of zinc on gut development and morphology in the offspring.
Zinc status influences and is influenced by multiple factors and an interdependence of prenatal and early life stress, immune system abnormalities, impaired GI functions, and zinc deficiency can be hypothesized.
In line with this, systemic inflammatory events and prenatal stress have been reported to increase the risk for ASD.
Thus, here, we will review the current literature on the role of zinc in gut formation, a possible link between gut and brain development in ASD and other neurological disorders with shared comorbidities, and tie in possible effects on the immune system.
Based on these data, we present a novel model outlining how alterations in the maternal zinc status might pathologically impact the offspring leading to impairments in brain functions later in life.
American Psychological Association (APA)
Vela, Guillermo& Stark, Peter& Socha, Michael& Sauer, Ann Katrin& Hagmeyer, Simone& Grabrucker, Andreas M.. 2015. Zinc in Gut-Brain Interaction in Autism and Neurological Disorders. Neural Plasticity،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075433
Modern Language Association (MLA)
Vela, Guillermo…[et al.]. Zinc in Gut-Brain Interaction in Autism and Neurological Disorders. Neural Plasticity No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1075433
American Medical Association (AMA)
Vela, Guillermo& Stark, Peter& Socha, Michael& Sauer, Ann Katrin& Hagmeyer, Simone& Grabrucker, Andreas M.. Zinc in Gut-Brain Interaction in Autism and Neurological Disorders. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075433