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Effects of Trace Metal Profiles Characteristic for Autism on Synapses in Cultured Neurons
Joint Authors
Hagmeyer, Simone
Grabrucker, Andreas M.
Mangus, Katharina
Boeckers, Tobias M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-23
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Various recent studies revealed that biometal dyshomeostasis plays a crucial role in the pathogenesis of neurological disorders such as autism spectrum disorders (ASD).
Substantial evidence indicates that disrupted neuronal homeostasis of different metal ions such as Fe, Cu, Pb, Hg, Se, and Zn may mediate synaptic dysfunction and impair synapse formation and maturation.
Here, we performed in vitro studies investigating the consequences of an imbalance of transition metals on glutamatergic synapses of hippocampal neurons.
We analyzed whether an imbalance of any one metal ion alters cell health and synapse numbers.
Moreover, we evaluated whether a biometal profile characteristic for ASD patients influences synapse formation, maturation, and composition regarding NMDA receptor subunits and Shank proteins.
Our results show that an ASD like biometal profile leads to a reduction of NMDAR (NR/Grin/GluN) subunit 1 and 2a, as well as Shank gene expression along with a reduction of synapse density.
Additionally, synaptic protein levels of GluN2a and Shanks are reduced.
Although Zn supplementation is able to rescue the aforementioned alterations, Zn deficiency is not solely responsible as causative factor.
Thus, we conclude that balancing Zn levels in ASD might be a prime target to normalize synaptic alterations caused by biometal dyshomeostasis.
American Psychological Association (APA)
Hagmeyer, Simone& Mangus, Katharina& Boeckers, Tobias M.& Grabrucker, Andreas M.. 2015. Effects of Trace Metal Profiles Characteristic for Autism on Synapses in Cultured Neurons. Neural Plasticity،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1075435
Modern Language Association (MLA)
Hagmeyer, Simone…[et al.]. Effects of Trace Metal Profiles Characteristic for Autism on Synapses in Cultured Neurons. Neural Plasticity No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1075435
American Medical Association (AMA)
Hagmeyer, Simone& Mangus, Katharina& Boeckers, Tobias M.& Grabrucker, Andreas M.. Effects of Trace Metal Profiles Characteristic for Autism on Synapses in Cultured Neurons. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1075435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075435