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Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus
Joint Authors
Jain, Khushbu
Prasad, Dipti
Singh, Shashi Bala
Kohli, Ekta
Source
Neurology Research International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Brain is predominantly susceptible to oxidative stress and mitochondrial dysfunction during hypobaric hypoxia, and therefore undergoes neurodegeneration due to energy crisis.
Evidences illustrate a high degree of association for mitochondrial fusion/fission imbalance and mitochondrial dysfunction.
Mitochondrial fusion/fission is a recently reported dynamic mechanism which frequently occurs among cellular mitochondrial network.
Hence, the study investigated the temporal alteration and involvement of abnormal mitochondrial dynamics (fusion/fission) along with disturbed mitochondrial functionality during chronic exposure to hypobaric hypoxia (HH).
The Sprague-Dawley rats were exposed to simulated high altitude equivalent to 25000 ft for 3, 7, 14, 21, and 28 days.
Mitochondrial morphology, distribution within neurons, enzyme activity of respiratory complexes, Δψm, ADP: ATP, and expression of fission/fusion key proteins were determined.
Results demonstrated HH induced alteration in mitochondrial morphology by damaged, small mitochondria observed in neurons with disturbance of mitochondrial functionality and reduced mitochondrial density in neuronal processes manifested by excessive mitochondrial fragmentation (fission) and decreased mitochondrial fusion as compared to unexposed rat brain hippocampus.
The study suggested that imbalance in mitochondrial dynamics is one of the noteworthy mechanisms occurring in hippocampal neurons during HH insult.
American Psychological Association (APA)
Jain, Khushbu& Prasad, Dipti& Singh, Shashi Bala& Kohli, Ekta. 2015. Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus. Neurology Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075454
Modern Language Association (MLA)
Jain, Khushbu…[et al.]. Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus. Neurology Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075454
American Medical Association (AMA)
Jain, Khushbu& Prasad, Dipti& Singh, Shashi Bala& Kohli, Ekta. Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus. Neurology Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075454