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Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus
Joint Authors
Gao, Chao
Cui, Yu-Gui
Gao, Li
Meng, Qian
Shao, Li
Luo, Xiucui
Mu, Yingping
Xu, Wen
Liu, Jiayin
Source
Obstetrics and Gynecology International
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
Gestational diabetes mellitus (GDM) leads to an abnormal placental environment which may cause some structural alterations of placenta and affect placental development and function.
In this study, the ultrastructural appearances of term placentas from women with GDM and normal pregnancy were meticulously compared.
Materials and Methods.
The placenta tissues of term birth from 10 women with GDM and 10 women with normal pregnancy were applied with the signed informed consent.
The morphology of fetomaternal interface of placenta was examined using light microscopy (LM) and transmission electron microscopy (TEM).
Results.
On LM, the following morphological changes in villous tissues were found in the GDM placentas when compared with the control placentas: edematous stroma, apparent increase in the number of syncytial knots, and perivillous fibrin deposition.
On TEM, the distinct ultrastructural alterations indicating the degeneration of terminal villi were found in the GDM placentas as follows: thickening of the basal membrane (BM) of vasculosyncytial membrane (VSM) and the VSM itself, significantly fewer or even absent syncytiotrophoblastic microvilli, swollen or completely destroyed mitochondria and endoplasmic reticulum, and syncytiotrophoblasts with multiple vacuoles.
Conclusion.
Ultrastructural differences exist between GDM and control placentas.
The differences of placenta ultrastructure are likely responsible for the impairment of placental barrier and function in GDM.
American Psychological Association (APA)
Meng, Qian& Shao, Li& Luo, Xiucui& Mu, Yingping& Xu, Wen& Gao, Chao…[et al.]. 2015. Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus. Obstetrics and Gynecology International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075498
Modern Language Association (MLA)
Meng, Qian…[et al.]. Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus. Obstetrics and Gynecology International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075498
American Medical Association (AMA)
Meng, Qian& Shao, Li& Luo, Xiucui& Mu, Yingping& Xu, Wen& Gao, Chao…[et al.]. Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus. Obstetrics and Gynecology International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075498