Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation
Joint Authors
Sart, Sébastien
Song, Liqing
Li, Yan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Reactive oxygen species (ROS) have long been considered as pathological agents inducing apoptosis under adverse culture conditions.
However, recent findings have challenged this dogma and physiological levels of ROS are now considered as secondary messengers, mediating numerous cellular functions in stem cells.
Stem cells represent important tools for tissue engineering, drug screening, and disease modeling.
However, the safe use of stem cells for clinical applications still requires culture improvements to obtain functional cells.
With the examples of mesenchymal stem cells (MSCs) and pluripotent stem cells (PSCs), this review investigates the roles of ROS in the maintenance of self-renewal, proliferation, and differentiation of stem cells.
In addition, this work highlights that the tight control of stem cell microenvironment, including cell organization, and metabolic and mechanical environments, may be an effective approach to regulate endogenous ROS generation.
Taken together, this paper indicates the need for better quantification of ROS towards the accurate control of stem cell fate.
American Psychological Association (APA)
Sart, Sébastien& Song, Liqing& Li, Yan. 2015. Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075523
Modern Language Association (MLA)
Sart, Sébastien…[et al.]. Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075523
American Medical Association (AMA)
Sart, Sébastien& Song, Liqing& Li, Yan. Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075523