TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans
Joint Authors
Havermann, Susannah
Wätjen, Wim
Büchter, Christian
Zhao, Liang
Honnen, Sebastian
Fritz, Gerhard
Proksch, Peter
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) was isolated from Polygonum multiflorum, a plant which is traditionally used as an anti-ageing drug.
We have analysed ageing-related effects of TSG in the model organism C.
elegans in comparison to resveratrol.
TSG exerted a high antioxidative capacity both in a cell-free assay and in the nematode.
The antioxidative capacity was even higher compared to resveratrol.
Presumably due to its antioxidative effects, treatment with TSG decreased the juglone-mediated induction of the antioxidative enzyme SOD-3; the induction of the GST-4 by juglone was diminished slightly.
TSG increased the resistance of C.
elegans against lethal thermal stress more prominently than resveratrol (50 μM TSG increased mean survival by 22.2%).
The level of the ageing pigment lipofuscin was decreased after incubation with the compound.
TSG prolongs the mean, median, and maximum adult life span of C.
elegans by 23.5%, 29.4%, and 7.2%, respectively, comparable to the effects of resveratrol.
TSG-mediated extension of life span was not abolished in a DAF-16 loss-of-function mutant strain showing that this ageing-related transcription factor is not involved in the effects of TSG.
Our data show that TSG possesses a potent antioxidative capacity, enhances the stress resistance, and increases the life span of the nematode C.
elegans.
American Psychological Association (APA)
Büchter, Christian& Zhao, Liang& Havermann, Susannah& Honnen, Sebastian& Fritz, Gerhard& Proksch, Peter…[et al.]. 2015. TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075528
Modern Language Association (MLA)
Büchter, Christian…[et al.]. TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075528
American Medical Association (AMA)
Büchter, Christian& Zhao, Liang& Havermann, Susannah& Honnen, Sebastian& Fritz, Gerhard& Proksch, Peter…[et al.]. TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075528