Vitamin A and Retinoids as Mitochondrial Toxicants
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Vitamin A and its derivatives, the retinoids, are micronutrient necessary for the human diet in order to maintain several cellular functions from human development to adulthood and also through aging.
Furthermore, vitamin A and retinoids are utilized pharmacologically in the treatment of some diseases, as, for instance, dermatological disturbances and some types of cancer.
In spite of being an essential micronutrient with clinical application, vitamin A exerts several toxic effects regarding redox environment and mitochondrial function.
Moreover, decreased life quality and increased mortality rates among vitamin A supplements users have been reported.
However, the exact mechanism by which vitamin A elicits its deleterious effects is not clear yet.
In this review, the role of mitochondrial dysfunction in the mechanism of vitamin A-induced toxicity is discussed.
American Psychological Association (APA)
de Oliveira, Marcos Roberto. 2015. Vitamin A and Retinoids as Mitochondrial Toxicants. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075532
Modern Language Association (MLA)
de Oliveira, Marcos Roberto. Vitamin A and Retinoids as Mitochondrial Toxicants. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075532
American Medical Association (AMA)
de Oliveira, Marcos Roberto. Vitamin A and Retinoids as Mitochondrial Toxicants. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075532