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Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer
Joint Authors
Muller, Christian D.
Minker, Carole
Duban, Livine
Karas, Daniel
Järvinen, Päivi
Lobstein, Annelise
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Scope.
The aim of this work is to identify which proapoptotic pathway is induced in human colon cancer cell lines, in contact with proanthocyanidins extracted from various berries.
Methods and Results.
Proanthocyanidins (Pcys) extracted from 11 berry species are monitored for proapoptotic activities on two related human colon cancer cell lines: SW480-TRAIL-sensitive and SW620-TRAIL-resistant.
Apoptosis induction is monitored by cell surface phosphatidylserine (PS) detection.
Lowbush blueberry extract triggers the strongest activity.
When tested on the human monocytic cell line THP-1, blueberry Pcys are less effective for PS externalisation and DNA fragmentation is absent, highlighting a specificity of apoptosis induction in gut cells.
In Pcys-treated gut cell lines, caspase 8 (apoptosis extrinsic pathway) but not caspase 9 (apoptosis intrinsic pathway) is activated after 3 hours through P38 phosphorylation (90 min), emphasizing the potency of lowbush blueberry Pcys to eradicate gut TRAIL-resistant cancer cells.
Conclusion.
We highlight here that berries Pcys, especially lowbush blueberry Pcys, are of putative interest for nutritional chemoprevention of colorectal cancer in view of their apoptosis induction in a human colorectal cancer cell lines.
American Psychological Association (APA)
Minker, Carole& Duban, Livine& Karas, Daniel& Järvinen, Päivi& Lobstein, Annelise& Muller, Christian D.. 2015. Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075537
Modern Language Association (MLA)
Minker, Carole…[et al.]. Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075537
American Medical Association (AMA)
Minker, Carole& Duban, Livine& Karas, Daniel& Järvinen, Päivi& Lobstein, Annelise& Muller, Christian D.. Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075537
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075537