Copper Uptake in Mammary Epithelial Cells Activates Cyclins and Triggers Antioxidant Response
Joint Authors
Kihara, Alexandre H.
dos Santos, Nathália Villa
Matias, Andreza Cândido
Higa, Guilherme Shigueto Vilar
Cerchiaro, Giselle
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The toxicologic effects of copper (Cu) on tumor cells have been studied during the past decades, and it is suggested that Cu ion may trigger antiproliferative effects in vitro.
However, in normal cells the toxicologic effects of high exposures of free Cu are not well understood.
In this work, Cu uptake, the expression of genes associated with cell cycle regulation, and the levels of ROS production and related oxidative processes were evaluated in Cu-treated mammary epithelial MCF10A nontumoral cells.
We have shown that the Cu additive is associated with the activation of cyclin D1 and cyclin B1, as well as cyclin-dependent kinase 2 (CDK2).
These nontumor cells respond to Cu-induced changes in the oxidative balance by increase of the levels of reduced intracellular glutathione (GSH), decrease of reactive oxygen species (ROS) generation, and accumulation during progression of the cell cycle, thus preventing the cell abnormal proliferation or death.
Taken together, our findings revealed an effect that contributes to prevent a possible damage of normal cells exposed to chemotherapeutic effects of drugs containing the Cu ion.
American Psychological Association (APA)
dos Santos, Nathália Villa& Matias, Andreza Cândido& Higa, Guilherme Shigueto Vilar& Kihara, Alexandre H.& Cerchiaro, Giselle. 2015. Copper Uptake in Mammary Epithelial Cells Activates Cyclins and Triggers Antioxidant Response. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075540
Modern Language Association (MLA)
dos Santos, Nathália Villa…[et al.]. Copper Uptake in Mammary Epithelial Cells Activates Cyclins and Triggers Antioxidant Response. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075540
American Medical Association (AMA)
dos Santos, Nathália Villa& Matias, Andreza Cândido& Higa, Guilherme Shigueto Vilar& Kihara, Alexandre H.& Cerchiaro, Giselle. Copper Uptake in Mammary Epithelial Cells Activates Cyclins and Triggers Antioxidant Response. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075540