Enhancement of the Acrolein-Induced Production of Reactive Oxygen Species and Lung Injury by GADD34
Joint Authors
Tanaka, Yuriko
Nishio, Naomi
Sun, Yang
Chen, Nana
Isobe, Ken-ichi
Liu, Lintao
Ito, Sachiko
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-03
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Chronic obstructive pulmonary disease (COPD) is characterized by lung destruction and inflammation.
As a major compound of cigarette smoke, acrolein plays a critical role in the induction of respiratory diseases.
GADD34 is known as a growth arrest and DNA damage-related gene, which can be overexpressed in adverse environmental conditions.
Here we investigated the effects of GADD34 on acrolein-induced lung injury.
The intranasal exposure of acrolein induced the expression of GADD34, developing the pulmonary damage with inflammation and increase of reactive oxygen species (ROS).
Conversely, the integrality of pulmonary structure was preserved and the generation of ROS was reduced in GADD34-knockout mice.
Acrolein-induced phosphorylation of eIF2α in GADD34-knockout epithelial cells by shRNA protected cell death by reducing misfolded protein-caused oxidative stress.
These data indicate that GADD34 participates in the development of acrolein-induced lung injury.
American Psychological Association (APA)
Sun, Yang& Ito, Sachiko& Nishio, Naomi& Tanaka, Yuriko& Chen, Nana& Liu, Lintao…[et al.]. 2015. Enhancement of the Acrolein-Induced Production of Reactive Oxygen Species and Lung Injury by GADD34. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075542
Modern Language Association (MLA)
Sun, Yang…[et al.]. Enhancement of the Acrolein-Induced Production of Reactive Oxygen Species and Lung Injury by GADD34. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1075542
American Medical Association (AMA)
Sun, Yang& Ito, Sachiko& Nishio, Naomi& Tanaka, Yuriko& Chen, Nana& Liu, Lintao…[et al.]. Enhancement of the Acrolein-Induced Production of Reactive Oxygen Species and Lung Injury by GADD34. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075542