P2X7 Receptor as a Key Player in Oxidative Stress-Driven Cell Fate in Nonalcoholic Steatohepatitis
Joint Authors
Chatterjee, Saurabh
Das, Suvarthi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Incidences of nonalcoholic fatty liver disease parallels increase in the global obesity epidemic.
NAFLD has been shown to be associated with risks of cardiometabolic disorders and kidney disturbances.
It is accompanied by insulin and leptin resistance that complicate the diagnosis and treatment of this public health menace.
Though significant research is underway for understanding the molecular mechanisms of NAFLD and its subsequent inflammatory and fibrotic manifestations like nonalcoholic steatohepatitis, the role of purinergic receptors has been unclear.
It is increasingly being recognized that damage associated molecular patterns like NAD and ATP that are released from injured cells via hepatocellular injury either by oxidative stress or lipotoxicity from steatosis activate the purinergic receptor.
Based on evidence from inflammatory responses in the airways and vasculature and autoimmune complications in humans and rodents, it is beyond doubt that hepatocellular inflammation such as that seen in NASH can result from the activation of purinergic receptors.
This event can result in the formation of inflammasomes and can be an important pathway for the progression of NASH.
The present review evaluates the current knowledge of the role of oxidative stress and its signaling via P2X7 receptors in hepatocellular injury that might contribute to the NASH pathophysiology.
American Psychological Association (APA)
Chatterjee, Saurabh& Das, Suvarthi. 2015. P2X7 Receptor as a Key Player in Oxidative Stress-Driven Cell Fate in Nonalcoholic Steatohepatitis. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075544
Modern Language Association (MLA)
Chatterjee, Saurabh& Das, Suvarthi. P2X7 Receptor as a Key Player in Oxidative Stress-Driven Cell Fate in Nonalcoholic Steatohepatitis. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075544
American Medical Association (AMA)
Chatterjee, Saurabh& Das, Suvarthi. P2X7 Receptor as a Key Player in Oxidative Stress-Driven Cell Fate in Nonalcoholic Steatohepatitis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075544