A New Approach to Oxidative Stress and Inflammatory Signaling during Labour in Healthy Mothers and Neonates
Joint Authors
Kajarabille, Naroa
Díaz-Castro, Javier
Ochoa, Julio J.
Florido, Jesus
Prados, Sonia
de Paco, Catalina
Ocon, Olga
Pulido-Moran, Mario
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of the current study was to investigate for the first time and simultaneously the oxidative stress and inflammatory signaling induced during the delivery in healthy mothers and their neonates.
56 mothers with normal gestational course and spontaneous delivery were selected.
Blood samples were taken from mother (before and after delivery) both from vein and artery of umbilical cord.
Lower antioxidant enzymes activities were observed in neonates compared with their mothers and lower oxidative stress in umbilical cord artery with respect to vein.
There was an overexpression of inflammatory cytokines in the mother, such as IL-6 and TNF-α, and, in addition, PGE2 was also increased.
Neonates showed lower levels of IL-6 and TNF-α and higher values of sTNF-RII and PGE2 in comparison with their mothers.
Parturition increases oxidative damage in the mother, although the indicators of oxidative damage were lower in umbilical cord artery with respect to umbilical vein.
The overexpression of inflammatory cytokines reveals that fetus suffers its own inflammatory process during parturition.
American Psychological Association (APA)
Díaz-Castro, Javier& Florido, Jesus& Kajarabille, Naroa& Prados, Sonia& de Paco, Catalina& Ocon, Olga…[et al.]. 2015. A New Approach to Oxidative Stress and Inflammatory Signaling during Labour in Healthy Mothers and Neonates. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075546
Modern Language Association (MLA)
Díaz-Castro, Javier…[et al.]. A New Approach to Oxidative Stress and Inflammatory Signaling during Labour in Healthy Mothers and Neonates. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075546
American Medical Association (AMA)
Díaz-Castro, Javier& Florido, Jesus& Kajarabille, Naroa& Prados, Sonia& de Paco, Catalina& Ocon, Olga…[et al.]. A New Approach to Oxidative Stress and Inflammatory Signaling during Labour in Healthy Mothers and Neonates. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075546