Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress
Joint Authors
Cheung, C. W.
Li, Sisi
Yang, Yang
Yu, Cong
Yao, Ying
Wu, Yujia
Qian, Lian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of the study was to determine whether or not dexmedetomidine- (DEX-) based intravenous infusion in dental implantation can provide better sedation and postoperative analgesia via suppressing postoperative inflammation and oxidative stress.
Sixty patients were randomly assigned to receive either DEX (group D) or midazolam (group M).
Recorded variables were vital sign (SBP/HR/RPP/SpO2/RR), visual analogue scale (VAS) pain scores, and observer’s assessment of alertness/sedation scale (OAAS) scores.
The plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), antioxidant superoxide dismutase (SOD), and the lipid peroxidation product malondialdehyde (MDA) were detected at baseline and after 2, 4, and 24 h of drug administration.
The VAS pain scores and OAAS scores were significantly lower for patients in group D compared to group M.
The plasma levels of TNF-α, IL-6, and MDA were significantly lower in group D patients than those in group M at 2 h and 4 h.
In group M, SOD levels decreased as compared to group D at 2 h and 4 h.
The plasma levels of TNF-α, IL-6, and MDA were positively correlated with VAS pain scores while SOD negatively correlated with VAS pain scores.
Therefore, DEX appears to provide better sedation during office-based artificial tooth implantation.
DEX offers better postoperative analgesia via anti-inflammatory and antioxidation pathway.
American Psychological Association (APA)
Li, Sisi& Yang, Yang& Yu, Cong& Yao, Ying& Wu, Yujia& Qian, Lian…[et al.]. 2015. Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075551
Modern Language Association (MLA)
Li, Sisi…[et al.]. Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075551
American Medical Association (AMA)
Li, Sisi& Yang, Yang& Yu, Cong& Yao, Ying& Wu, Yujia& Qian, Lian…[et al.]. Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075551