Cardiopulmonary Bypass and Oxidative Stress
Joint Authors
Zakkar, Mustafa
Guida, Gustavo
Suleiman, M.-Saadeh
Angelini, Gianni D.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The development of the cardiopulmonary bypass (CPB) revolutionized cardiac surgery and contributed immensely to improved patients outcomes.
CPB is associated with the activation of different coagulation, proinflammatory, survival cascades and altered redox state.
Haemolysis, ischaemia, and perfusion injury and neutrophils activation during CPB play a pivotal role in oxidative stress and the associated activation of proinflammatory and proapoptotic signalling pathways which can affect the function and recovery of multiple organs such as the myocardium, lungs, and kidneys and influence clinical outcomes.
The administration of agents with antioxidant properties during surgery either intravenously or in the cardioplegia solution may reduce ROS burst and oxidative stress during CPB.
Alternatively, the use of modified circuits such as minibypass can modify both proinflammatory responses and oxidative stress.
American Psychological Association (APA)
Zakkar, Mustafa& Guida, Gustavo& Suleiman, M.-Saadeh& Angelini, Gianni D.. 2015. Cardiopulmonary Bypass and Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075554
Modern Language Association (MLA)
Zakkar, Mustafa…[et al.]. Cardiopulmonary Bypass and Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075554
American Medical Association (AMA)
Zakkar, Mustafa& Guida, Gustavo& Suleiman, M.-Saadeh& Angelini, Gianni D.. Cardiopulmonary Bypass and Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075554