Polyphenols as Modulators of Aquaporin Family in Health and Disease
Joint Authors
Fiorentini, Diana
Vieceli Dalla Sega, Francesco
Hrelia, Silvana
Zambonin, Laura
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Polyphenols are bioactive molecules widely distributed in fruits, vegetables, cereals, and beverages.
Polyphenols in food sources are extensively studied for their role in the maintenance of human health and in the protection against development of chronic/degenerative diseases.
Polyphenols act mainly as antioxidant molecules, protecting cell constituents against oxidative damage.
The enormous number of polyphenolic compounds leads to huge different mechanisms of action not fully understood.
Recently, some evidence is emerging about the role of polyphenols, such as curcumin, pinocembrin, resveratrol, and quercetin, in modulating the activity of some aquaporin (AQP) isoforms.
AQPs are integral, small hydrophobic water channel proteins, extensively expressed in many organs and tissues, whose major function is to facilitate the transport of water or glycerol over cell plasma membranes.
Here we summarize AQP physiological functions and report emerging evidence on the implication of these proteins in a number of pathophysiological processes.
In particular, this review offers an overview about the role of AQPs in brain, eye, skin diseases, and metabolic syndrome, focusing on the ability of polyphenols to modulate AQP expression.
This original analysis can contribute to elucidating some peculiar effects exerted by polyphenols and can lead to the development of an innovative potential preventive/therapeutic strategy.
American Psychological Association (APA)
Fiorentini, Diana& Zambonin, Laura& Vieceli Dalla Sega, Francesco& Hrelia, Silvana. 2015. Polyphenols as Modulators of Aquaporin Family in Health and Disease. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075556
Modern Language Association (MLA)
Fiorentini, Diana…[et al.]. Polyphenols as Modulators of Aquaporin Family in Health and Disease. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075556
American Medical Association (AMA)
Fiorentini, Diana& Zambonin, Laura& Vieceli Dalla Sega, Francesco& Hrelia, Silvana. Polyphenols as Modulators of Aquaporin Family in Health and Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075556