Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender
Joint Authors
Molinari, Nicolas
Maury, Jonathan
Gouzi, Farés
De Rigal, Philippe
Heraud, Nelly
Pomiès, Pascal
Laoudj-Chenivesse, Dalila
Mercier, Jacques
Préfaut, Christian
Hayot, Maurice
Pincemail, Joël
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Oxidative stress (OS) plays a key role in the muscle impairment and exercise capacity of COPD patients.
However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation.
This study therefore aimed to identify OS markers imbalance of COPD patients, relative to validated normal reference values, and to investigate the possibility of systemic OS profiles.
We measured systemic enzymatic/nonenzymatic antioxidant and lipid peroxidation (LP) levels in 54 stable COPD patients referred for a rehabilitation program.
The main systemic antioxidant deficits in these patients concerned vitamins and trace elements.
Fully 89% of the COPD patients showed a systemic antioxidant imbalance which may have caused the elevated systemic LP levels in 69% of them.
Interestingly, two patient profiles (clusters 3 and 4) had a more elevated increase in LP combined with increased copper and/or decreased vitamin C, GSH, and GPx.
Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity.
Our present data therefore support future supplementations with antioxidant vitamins and trace elements to improve exercise capacity, but COPD patients will probably show different positive responses.
American Psychological Association (APA)
Maury, Jonathan& Gouzi, Farés& De Rigal, Philippe& Heraud, Nelly& Pincemail, Joël& Molinari, Nicolas…[et al.]. 2015. Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075558
Modern Language Association (MLA)
Maury, Jonathan…[et al.]. Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075558
American Medical Association (AMA)
Maury, Jonathan& Gouzi, Farés& De Rigal, Philippe& Heraud, Nelly& Pincemail, Joël& Molinari, Nicolas…[et al.]. Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075558
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075558