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Serum Oxidative Stress Markers and Genotoxic Profile Induced by Chemotherapy in Patients with Breast Cancer: A Pilot Study
Joint Authors
de Freitas, Rivelilson Mendes
Júnior, Antonio Luiz Gomes
Paz, Marcia Fernanda Correia Jardim
Silva, Laís Iasmin Soares da
Carvalho, Simone da Costa e Silva
Sobral, André Luiz Pinho
Machado, Kátia da Conceição
Ferreira, Paulo Michel Pinheiro
Satyal, Prabodh
Cavalcante, Ana Amélia de Carvalho Melo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of this study was to evaluate the oxidative parameters of erythrocytes and genotoxicity in leukocytes of patients with breast cancer.
Oxidative parameters were detected by spectrophotometry and genotoxic damage by single cell gel electrophoresis.
Twenty-eight women with breast cancer were monitored before chemotherapy and after the second and fourth cycles of therapy with cyclophosphamide and doxorubicin.
After the fourth cycle, increases (P<0.05) in the reactive substances to thiobarbituric acid levels, nitrite content, and superoxide dismutase activity and high rates of DNA damage in leukocytes were observed when compared with healthy women group and baseline levels.
Similarly, after the second cycle, the same parameters were increased (P<0.05) when compared with baseline levels.
Increase in catalase activity was detected only after the fourth cycle and reduced glutathione levels and glutathione peroxidase activity were decreased in all cycles when compared with healthy women, as well as after the second and fourth chemotherapy cycles compared to baseline (P<0.05).
Patients with breast cancer presented an indicative of oxidative stress before, during, and after chemotherapy, as well as increased genotoxic damage in all stages of treatment, demonstrating the clinical applicability of this investigation.
American Psychological Association (APA)
Júnior, Antonio Luiz Gomes& Paz, Marcia Fernanda Correia Jardim& Silva, Laís Iasmin Soares da& Carvalho, Simone da Costa e Silva& Sobral, André Luiz Pinho& Machado, Kátia da Conceição…[et al.]. 2015. Serum Oxidative Stress Markers and Genotoxic Profile Induced by Chemotherapy in Patients with Breast Cancer: A Pilot Study. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075561
Modern Language Association (MLA)
Júnior, Antonio Luiz Gomes…[et al.]. Serum Oxidative Stress Markers and Genotoxic Profile Induced by Chemotherapy in Patients with Breast Cancer: A Pilot Study. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075561
American Medical Association (AMA)
Júnior, Antonio Luiz Gomes& Paz, Marcia Fernanda Correia Jardim& Silva, Laís Iasmin Soares da& Carvalho, Simone da Costa e Silva& Sobral, André Luiz Pinho& Machado, Kátia da Conceição…[et al.]. Serum Oxidative Stress Markers and Genotoxic Profile Induced by Chemotherapy in Patients with Breast Cancer: A Pilot Study. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075561